Unsuccessful at weight loss? What if I told you it’s all in your head? Really. Research from UT Southwestern Medical Center has shown that certain foods work with your brain to sabotage your efforts. The researchers found that specific fats, once ingested, make a beeline for the brain. Upon arriving at the brain, these fats simply shut off the satiety switch and instead cause the brain to send messages to the body telling it to ignore any appetite-suppressing signals from hormones such as insulin and leptin.